| Drug | Nebulizer Concentration (mM) | Treatment | Duration (weeks) | Aerosol Concentration (mg/l) | RMV (l/min) | D (min) | BW (kg) | DF | TRE Dose* Total (μg/kg) | DF | TRE Dose** Pulmonary (μg/kg) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| TRE | 0.5 | 4× daily | 5 | 6.1 | 0.3 | 15 | 0.44 | 1 | 64.9 | 0.1 | 6.5 |
BW, body weight; C, aerosol concentration; D, duration of exposure; DF, deposition fraction assumed as being 100% for the calculation of total delivered dose and 10% for the calculation of pulmonary delivered dose; RMV, respiratory minute volume from the formula RMV = 0.608 × BW0.852 (Alexander et al., 2008).
