TABLE 1

Inhalation drug dose calculations for administration of TPIP and TRE in the 8-week Sugen 5416/hypoxia study

DrugAerosolization (mg)TreatmentDuration (weeks)Aerosol Concentration (μg/l)RMV (l/min)D (min)BW (kg)DFTP Dose* Total (μg/kg)DFTP Dose** Pulmonary (μg/kg)
TPIP90once daily52.60.32330.48158.50.15.8
TPIP170once daily54.70.32370.471116.80.111.7