TABLE 1

Body weight, hemodynamic parameters and biochemistry data for BDL rats with or without empagliflozin treatment

ItemSham+vehicle
(n=9)
BDL+vehicle
(n=9)
BDL+empagliflozin (n=9)
BW1 (g)307 ± 9312 ± 8311 ± 13
BW2 (g)411 ± 30357 ± 59 a341 ± 22 a
MAP (mmHg)145 ± 12120 ± 11 a125 ± 21 a
PP (mmHg)8.5 ± 0.716.3 ± 3.8 a16.4 ± 3.6 a
HR (beats/min)402 ± 33397 ± 42376 ± 50
PVf (ml/min/100g)10.3 ± 2.310.3 ± 4.212.2 ± 2.7
SMAf (ml/min/100g)6.9 ± 2.48.0 ± 2.99.1 ± 2.0
SVR (mmHg/ml/min/100g)4.8 ± 0.73.8 ± 1.2 a3.3 ± 0.6 a
CI (ml/min/100g)30.6 ± 3.433.3 ± 8.338.3 ± 5.4 a
Ammonia (μmol/L)83 ± 56216 ± 67 a241 ± 70 a
ALT (IU/L)134 ± 59309 ± 182 a298 ± 142 a
TB (mg/dL)0.03 ± 0.018.7 ± 2.1 a7.7 ± 1.2 a
Cr (mg/dL)0.3 ± 0.10.4 ± 0.10.4 ± 0.1
Glu (mg/dL)113 ± 592 ± 11 a87 ± 15 a
  • BW1, body weight before treatment; BW2, body weight after treatment; PaO2, partial pressure of oxygen TB, total bilirubin; Cr, creatinine; Glu, fasting glucose; ap < 0.05 compared with the Sham+vehicle group.