TABLE 1

Effects of 8-aminopurines on urine volume (all values are in units of µl per 30 min)

All groups received their respective treatments just after period 1 (basal period). The 8-aminopurines were administered intravenously at 33.5 µmol/kg. P values are from repeated-measures one-factor analysis of variance. Values are means ± S.E.M.

Treatment GroupPeriod 1
(0–30 min)
Period 2
(40–70 min)
Period 3
(85–115 min)
P Value
Vehicle group (n = 6)94 ± 25110 ± 19119 ± 19NS
8-Aminoguanine (n = 5)75 ± 2448 ± 13344 ± 92a,bP = 0.0003
8-Aminoinosine (n = 9)69 ± 7274 ± 80a371 ± 142aP = 0.0012
8-Aminohypoxanthine (n = 6)94 ± 17301 ± 69a463 ± 40a,bP < 0.0001
  • NS, not significant; n, sample size.

  • aP < 0.05 versus period 1 in Bonferroni test.

  • bP < 0.05 versus period 2 in Bonferroni test.