TABLE 5

Effects of 8-aminopurines on mean arterial blood pressure, heart rate, renal blood flow, and mesenteric blood flow

All groups received their respective treatments just after period 1 (basal period). The 8-aminopurines were administered intravenously at 33.5 µmol/kg. P values are from repeated-measures one-factor analysis of variance. Values are means ± S.E.M.

Period 1Period 2Period 3P Value
Mean Arterial Blood Pressure (mm Hg)
Vehicle
(n = 6)
112 ± 4108 ± 3107 ± 3NS
8-Aminoguanine
(n = 5)
102 ± 5103 ± 4103 ± 4NS
8-Aminoinosine
(n = 9)
108 ± 3114 ± 4109 ± 2NS
8-Aminohypoxanthine
(n = 6)
110 ± 3120 ± 8117 ± 6NS
Heart Rate (beats/min)
Vehicle
(n = 6)
404 ± 12390 ± 16384 ± 20NS
8-Aminoguanine
(n = 5)
377 ± 13372 ± 14372 ± 13NS
8-Aminoinosine
(n = 9)
398 ± 16395 ± 14389 ± 14NS
8-Aminohypoxanthine
(n = 6)
393 ± 7380a ± 4372a ± 60.0005
Renal Blood Flow (ml/min)
Vehicle
(n = 6)
7.8 ± 1.27.8 ± 1.18.2 ± 1.0NS
8-Aminoguanine
(n = 5)
5.9 ± 0.75.2 ± 0.65.5 ± 0.8NS
8-Aminoinosine
(n = 9)
7.4 ± 0.56.6 ± 0.56.8 ± 0.4NS
8-Aminohypoxanthine
(n = 6)
8.2 ± 0.96.7a ± 0.56.8a ± 0.60.0244
Mesenteric Blood Flow (ml/min)
Vehicle
(n = 6)
13.3 ± 2.413.0 ± 2.012.7 ± 1.8NS
8-Aminoguanine
(n = 5)
9.8 ± 2.210.8 ± 2.413.1 ± 2.6NS
8-Aminoinosine
(n = 9)
11.8 ± 1.011.9 ± 1.111.3 ± 1.1NS
8-Aminohypoxanthine
(n = 6)
14.5 ± 3.116.1b ± 3.612.8 ± 2.30.0400
  • NS, not significant; n, sample size.

  • aP < 0.05 versus period 1.

  • bP < 0.05 versus period 3.