TABLE 2

Effects of 8-aminopurines on sodium excretion (all values are in units of µmoles per 30 min)

All groups received their respective treatments just after period 1 (basal period). The 8-aminopurines were administered intravenously at 33.5 µmol/kg. P values are from repeated-measures one-factor analysis of variance. Values are means ± S.E.M.

Treatment GroupPeriod 1
(0–30 min)
Period 2
(40–70 min)
Period 3
(85–115 min)
P Value
Vehicle group (n = 6)3.3 ± 1.04.4 ± 1.44.6 ± 1.8NS
8-Aminoguanine (n = 5)3.0 ± 0.911.0 ± 3.667.2 ± 12.3a,bP < 0.0001
8-Aminoinosine (n = 9)2.7 ± 0.512.8 ± 4.0a24.2 ± 10.7aP = 0.0008
8-Aminohypoxanthine (n = 6)3.3 ± 0.623.0 ± 8.8a49.4 ± 7.9a,bP < 0.0001
  • NS, not significant; n, sample size.

  • aP < 0.05 versus period 1 in Bonferroni test

  • bP < 0.05 versus period 2 in Bonferroni test.