TABLE 4

Effects of 8-aminopurines on potassium excretion (all values are in units of µmoles per 30 min)

All groups received their respective treatments just after period 1 (basal period). The 8-aminopurines were administered intravenously at 33.5 µmol/kg. P values are from repeated-measures one-factor analysis of variance. Values are means ± S.E.M.

Treatment GroupPeriod 1
(0–30 min)
Period 2
(40–70 min)
Period 3
(85–115 min)
P Value
Vehicle group (n = 6)34.5 ± 11.736.7 ± 8.851.1 ± 10.7NS
8-Aminoguanine (n = 5)21.3 ± 6.81.9 ± 0.4a9.2 ± 2.4bP = 0.0003
8-Aminoinosine (n = 9)25.0 ± 4.624.8 ± 8.526.9 ± 9.0NS
8-Aminohypoxanthine (n = 6)24.9 ± 3.830.3 ± 14.830.0 ± 5.7NS
  • NS, not significant; n, sample size.

  • aP < 0.05 versus period 1 in Bonferroni test.

  • bP < 0.05 versus period 2 in Bonferroni test.