TABLE 3

Effects of 8-aminopurines on glucose excretion (all values are in units of µg per 30 min)

All groups received their respective treatments just after period 1 (basal period). The 8-aminopurines were administered intravenously at 33.5 µmol/kg. P values are from repeated-measures one-factor analysis of variance. Values are means ± S.E.M.

Treatment GroupPeriod 1
(0–30 min)
Period 2
(40–70 min)
Period 3
(85–115 min)
P Value
Vehicle group (n = 6)7.1 ± 2.47.6 ± 2.69.0 ± 2.4NS
8-Aminoguanine (n = 5)3.5 ± 0.935.7 ± 8.9a269 ± 55a,bP < 0.0001
8-Aminoinosine (n = 9)3.6 ± 0.811.7 ± 3.9a8.1 ± 2.0aP = 0.0116
8-Aminohypoxanthine (n = 6)6.1 ± 1.118.4 ± 4.5a28.6 ± 6.0a,bP = 0.0002
  • NS, not significant; n, sample size.

  • aP < 0.05 versus period 1 in Bonferroni test.

  • bP < 0.05 versus period 2 in Bonferroni test.