Summary pharmacokinetic parameters for loperamide and OMI in ICR mice after oral administration alone and in combination
A two-tailed unpaired t test was performed to compare AUCs among tissues (see results) and between the same tissues in discrete vs. combination studies (*P = 0.014). Results are presented as mean or mean ± S.D.
| Parameter | Loperamide Alone (30 mg/kg) | Loperamide in Combination (30 mg/kg) | OMI Alone (30 mg/kg) | OMI in Combination (30 mg/kg) |
|---|---|---|---|---|
| t1/2 (h) | 7 | 3.1 | 2.5 | 4.5 |
| CL/F (l/h)/kg | 19 | 15.5 | 22.3 | 51.2 |
| V/F l/kg | 192 | 70.3 | 80 | 162 |
| Cmax (ng/ml) | 235 | 370 | 345 | 186 |
| tmax (h) | 0.5 | 4 | 1 | 0.5 |
| AUC0→∞ Plasma (h*ng)/ml | 1577 ± 427 | 1936 ± 290 | 1386 ± 191* | 745 ± 166* |
| AUC0→∞Brain (h*ng)/g | 94 ± 13 | 162 ± 40 | 1762 ± 296 | 1121 ± 262 |
| AUC0→∞ Spinal Cord (h*ng)/g | 304 ± 220 | 223 ± 44 | 744 ± 273 | 615 ± 262 |
| KpBrain | 0.06 | 0.08 | 1.27 | 1.5 |
| KpSpinal Cord | 0.19 | 0.12 | 0.54 | 0.82 |
| F | 0.19 | 0.25 | 0.55 | 0.17 |