Parameter | Estimates (RSE%) | ||
---|---|---|---|
Rat | Monkey | Human | |
Emax | 1 fixed | 1 fixed | 0.670 |
Logit for Emax | — | — | 0.707 (16.3) |
EC50 (ng/ml) | 0.196 (22.7) | 0.416 (29.3) | 0.292 (7.60) |
Hill | 1.50 (7.33) | 1.71 (26.3) | 2.44 (8.44) |
E0 (ng/mla or ng×h/mlb) | 1170 (8.47)a | 78.9 (11.2)b | 50.7 (9.90)b |
ω2 Logit for Emax | — | — | 0.520 (51.3) |
ω2 EC50 | — | 0.693 (48.5) | — |
ω2 E0 | — | — | 0.219 (30.0) |
σ2 Proportional | 0.195 (28.3) | 0.128 (29.0) | 0.0260 (14.0) |
ω2, interindividual variance estimate for each parameter; σ2, proportional residual error variance; RSE%, relative standard error (standard error as a percentage of estimate).