TABLE 1

Pharmacokinetic parameters of HCQ from whole blood in non–tumor-bearing and tumor-bearing mice after a single intraperitoneal dose

Dose
Non–Tumor-Bearing Balb/c MiceMDA-MB-231 Tumor– Bearing Nude Mice
PK ParameterUnits20 mg/kg40 mg/kg80 mg/kg60 mg/kg
Cmaxµg/ml1.363.124.663.56
Tmaxh3333
t1/2λh24.111.213.410.2
AUC0-infµg•h/ml13.5524.2640.3929.66
AUC0-24hµg•h/ml9.0917.6430.3122.34
*CLl/h/kg1.491.651.982.02
MRTh16.29.08.88.9
*VDzl/kg51.626.630.039.0
  • CL, clearance; MRT, mean resistance time; t1/2λ, terminal half-life; VDz, apparent volume of distribution.

  • *CL and VDz calculations represent values that are not dose-corrected for the bioavailability, and total dose was used in the calculation.