Dose | |||||
---|---|---|---|---|---|
Non–Tumor-Bearing Balb/c Mice | MDA-MB-231 Tumor– Bearing Nude Mice | ||||
PK Parameter | Units | 20 mg/kg | 40 mg/kg | 80 mg/kg | 60 mg/kg |
Cmax | µg/ml | 1.36 | 3.12 | 4.66 | 3.56 |
Tmax | h | 3 | 3 | 3 | 3 |
t1/2λ | h | 24.1 | 11.2 | 13.4 | 10.2 |
AUC0-inf | µg•h/ml | 13.55 | 24.26 | 40.39 | 29.66 |
AUC0-24h | µg•h/ml | 9.09 | 17.64 | 30.31 | 22.34 |
*CL | l/h/kg | 1.49 | 1.65 | 1.98 | 2.02 |
MRT | h | 16.2 | 9.0 | 8.8 | 8.9 |
*VDz | l/kg | 51.6 | 26.6 | 30.0 | 39.0 |
CL, clearance; MRT, mean resistance time; t1/2λ, terminal half-life; VDz, apparent volume of distribution.
*CL and VDz calculations represent values that are not dose-corrected for the bioavailability, and total dose was used in the calculation.