Effect of chronic compound-1 on plasma parameters in WD-fed MC4R KO mice
| Mice | WT | WD-Fed MC4R KO | ||||
|---|---|---|---|---|---|---|
| Treatment | Vehicle (n = 5) | Vehicle (n = 8) | Compound-1 | |||
| 3 mg/kg (n = 8) | 10 mg/kg (n = 8) | 30 mg/kg (n = 8) | ||||
| AST (IU/l) | Pre | 41.8 ± 7.0 | 636.9 ± 96.4$$$ | 601.7 ± 108.6 | 613.2 ± 101.7 | 620.7 ± 92.3 |
| Post | 64.3 ± 12.8 | 649.6 ± 86.7 | 526.4 ± 84.6¶ | 268.9 ± 61.7¶¶ | 105.3 ± 8.0¶¶ | |
| ALT (IU/l) | Pre | 22.1 ± 4.6 | 857.6 ± 103.9$$$ | 849.5 ± 133.2 | 860.2 ± 118.8 | 858.9 ± 113.1 |
| Post | 20.4 ± 14.1 | 840.7 ± 124.4 | 612.2 ± 94.2¶ | 283.9 ± 74.0¶¶ | 54.6 ± 9.1¶¶ | |
| TG (mg/dl) | Pre | 132.0 ± 16.0 | 85.1 ± 15.9### | 88.2 ± 22.7 | 75.5 ± 15.1 | 81.7 ± 25.8 |
| Post | 117.5 ± 39.6 | 75.2 ± 9.3 | 132.0 ± 36.2¶¶ | 146.0 ± 31.9¶¶ | 159.3 ± 73.8¶¶ | |
| T-Cho (mg/dl) | Pre | 95.5 ± 6.2 | 405.5 ± 22.4$$$ | 393.1 ± 38.3 | 387.2 ± 26.6 | 403.0 ± 31.3 |
| Post | 97.0 ± 5.0 | 429.2 ± 18.6 | 390.4 ± 37.7* | 305.3 ± 37.2*** | 164.8 ± 25.4*** | |
Plasma parameters were measured before (Pre) and after (Post) 8 weeks of treatment.
Data are presented as the mean ± S.D. (n = 5–8).
###P < 0.001 vs. vehicle-treated WT mice by Student’s t test; $P < 0.001 vs. vehicle-treated WT mice by Aspin–Welch test; *P < 0.05 and ***P < 0.001 vs. vehicle-treated WD-fed MC4R KO mice by Dunnett’s test; ¶P < 0.05 and ¶¶P < 0.01 vs. vehicle-treated WD-fed MC4R KO mice by Steel’s test.