PK parameters of nemvaleukin in male cynomolgus monkeys after a single intravenous (0.3 mg/kg) or subcutaneous (0.3 or 1.0 mg/kg) dose
| Dose Route | Dose | Cmax | Tmax | AUC∞ | t1/2 | MRT | CL | Vdss |
|---|---|---|---|---|---|---|---|---|
| mg/kg | ng/ml | h | ng·h/ml | h | h | ml/h/kg | ml/kg | |
| Intravenous | 0.3 | 6119 ± 1188 | 0.083(0.083, 0.083) | 28,460 ± 1230 | 49.5 ± 5.6 | 12.8 ± 1.9 | 10.6 ± 0.46 | 135 ± 16.6 |
| Subcutaneous | 0.3 | 549 ± 208 | 8 (8, 8) | 12,931 ± 3893 | 61.9 ± 4.6 | 31.6 ± 4.0 | — | — |
| Subcutaneous | 1.0 | 1035 ± 133 | 8 (8, 8) | 26,878 ± 2106 | 37.3 ± 19.4 | 21.7 ± 2.8 | — | — |
N = 3 per treatment group.
Mean (± S.D.) for all parameters except Tmax [median (min, max)].