Potency of nemvaleukin on selected lymphocyte subsets from cynomolgus monkey and human samples (Lopes et al., 2020)
| Lymphocyte Population | Monkey EC50 Mean ± S.D. | Humana EC50 Mean ± S.D. |
|---|---|---|
| nM | nM | |
| NK cells | 0.47 ± 0.22 | 0.45 ± 0.09 |
| Naïve CD8+ T cells | 1.4 ± 0.3 | 2.2 ± 1.0 |
| Central/transitional memory CD8+ T cells | 1.3 ± 0.4 | 1.1 ± 0.1 |
| Effector memory CD8+ T cells | 2.0 ± 1.0 | 1.25 ± 0.4 |
| Terminal effector CD8+ T cells | 1.7 ± 0.8 | 0.93 ± 0.3 |
| Tregs | 0.50 ± 0.14 | 0.59 ± 0.2 |
↵aData generated from three separate experiments, each performed in triplicate, and the error represents S.D.