TABLE 3

PK parameters of nemvaleukin in male cynomolgus monkeys after repeated intravenous (0.1 mg/kg for 5 consecutive days, on days 1–5) or subcutaneous (0.5 mg/kg on days 1 and 4) doses

Dose route	Dose	Day	C_max	T_max	C_trough	AUC_τ^a	AUC_t	AUC_total
	mg/kg		ng/ml	h	ng/ml	ng·h/ml	ng·h/ml	ng·h/ml
Intravenous	0.1	1	2575 ± 176	0.083 (0.083, 0.083)	<LLOQ	9035 ± 602	9035 ± 602	41,753 ± 2213^b
		5	2096 ± 80	0.083 (0.083, 0.083)	9.62 ± 1.39	5159 ± 301	5611 ± 429	30,124 ± 1112^c
		Subcutaneous	0.5	1	911 ± 432	8 (8, 8)	<LLOQ	17,656 ± 6700	17,656 ± 6700	33,402 ± 9204
4	1006 ± 119			2 (2, 8)	10.0 ± 1.25	15,214 ± 2529	15,746 ± 2601			33,402 ± 9204

N = 3 per treatment group, LLOQ = 1.00 ng/ml.
Mean (± S.D.) for all parameters except T_max [median (min, max)].
↵^aτ = 24 hours for intravenous dosing regimen and 72 hours for subcutaneous dosing regimen.
↵^bCalculated based on AUC_{24h,day 1} × 4 + AUC_{t,day 5}.
↵^cCalculated based on AUC_{24h,day 1} + AUC_{24h,day 5} × 3 + AUC_{t,day 5}.