Pharmacokinetic parameters of hMSC in liver and lung after prazosin administration
| Pharmacokinetic parameter | Liver | Lung | ||
|---|---|---|---|---|
| hMSC | Prazosin + hMSC | hMSC | Prazosin + hMSC | |
| AUClast0–2 (h× FU×106) | 193.4 ± 14.4 | 228.4 ± 16.3 | 746.4 ± 38 | 999 ± 40.3** |
| AUClast2–8 (h×FU×106) | 419.9 ± 34.7 | 660.3 ± 67.6 | 2123 ± 94.9 | 2612 ± 151.4** |
| Tmax (h) | 1 | 0.5 | 0.25 | 1 |
| Cmax (FU×106) | 113.4 ± 21.5 | 152.3 ± 21.0 | 448.3 ± 51.7 | 561.7 ± 26.5* |
FU, fluorescent units; Tmax, peak time. *P < 0.05; **P < 0.01 compared with the hMSC group.