Concentrations of trazpiroben in plasma and CSF after multiple oral doses in the rat and dog on day 4
| Animal | Trazpiroben Concentration (ng/ml), Mean (S.D.) | |||
|---|---|---|---|---|
| Plasma | CSF | |||
| 1 h postdose | 3 h postdose | 1 h postdose | 3 h postdose | |
| Rat (trazpiroben 100 mg/kg/day) | ||||
| Male | 916 (413) | – | 0.99 (1.11) | – |
| Female | 1475 (615) | – | 2.42 (1.03) | – |
| Male + femalea | 1195 (575) | – | 1.70 (1.26) | – |
| Dog (trazpiroben 50 mg/kg/day) | ||||
| Male | 2698 (3115) | 2145 (973) | 2.94 (3.00) | 8.93 (4.07) |
| Female | 1991 (2514) | 1832 (1771) | 3.71 (3.67) | 6.19 (3.74) |
| Male + femalea | 2345 (2695) | 1989 (1357) | 3.33 (3.19) | 7.56 (3.96) |
–, not available.
aCombined mean (S.D.) for males and females.