TABLE 3

Protein binding of verinurad and metabolites M1 and M8 in human plasma, HSA, and AGP

% Protein Binding (Mean ± S.D., N = 3)
Test Compound1 µM10 µM50 µM
VerinuradPlasma97.4 ± 0.397.3 ± 0.196.7 ± 0.1
HSA97.3 ± 0.396.8 ± 0.396.3 ± 0.1
AGP9.8 ± 0.98.4 ± 2.58.6 ± 1.7
M1Plasma92.4 ± 0.2191.6 ± 0.28
M8Plasma65.2 ± 0.2367.2 ± 2.17
  • AGP, α-1-acid glycoprotein; HSA, human serum albumin; SD, standard deviation.