Summary of PK parameters of ipatasertib after single oral dose of ipatasertib 100 mg alone or coadministered with itraconazole 200 mg
All values are reported as geometric mean (geo% CV); tmax is reported as median (range); t1/2 is reported as mean (S.D.).
| Ipatasertib PK Parameters | Ipatasertib (100 mg) | Ipatasertib (100 mg) + Itraconazole (200 mg) |
|---|---|---|
| N = 15 | N = 15 | |
| AUC0-∞ (ng*h/mL) | 327 (26.4) | 1780 (22.6) |
| AUC0-72 (ng*h/mL) | 271 (25.5) | 1300 (22.9) |
| Cmax (ng/mL) | 44.9 (35.9) | 102 (34.1) |
| tmax (h) | 1.07 (0.50, 3.03) | 2.05 (1.00, 6.00) |
| t1/2 (h) | 44.0 (8.52) | 67.2 (9.20) |
| CL/F (L/h) | 306 (26.4) | 56.2 (22.6) |
| Vz/F (L) | 19100 (20.0) | 5400 (33.9) |