TABLE 5

Transport of fluorescent bile acid derivatives by efflux transporters

Transport experiments were performed as described in Material and Methods. The substrate conc. were 5 µM, and transport was measured for 5 minutes. Uptake values were corrected for uptake in the absence of ATP. Results are given in picomole per milligram protein × 5 minutes. Data are mean ± S.D. from two to four independent experiments with three technical replicates.

CompoundBSEPMRP2
CenNBDNTNT
CenDNSNTNT
CenPB81.4 ± 75.1NT
CDCenNBDNTNT
CDCenDNSNTNT
CDCenPB115 ± 103404 ± 355
AcenNBDNTNT
AcenDNSNTNT
AcenPBNTNT
  • NT, no transport.