TABLE 1

RV contractility and hypertrophy in Nx control vs. PH groups

The statistical differences between groups was determined by two-way ANOVA followed by Sidak’s post hoc test.

Nx (n = 11)Nx + 4091 (n = 6)Hx (n = 9)Hx + 4091 (n = 11)Hx + SU (n = 7)Hx + SU + 4091 (n = 6)
RV dP/dt max (mm Hg/s)1664 ± 3911343 ± 2892706 ± 703*1647 ± 114
RV −dP/dt min (mm Hg/s)5266 ± 10295890 ± 5704945 ± 7884753 ± 5534648 ± 10994504 ± 1302
Fulton’s index, RV/LV + S0.225 ± 0.0350.249 ± 0.0400.385 ± 0.080***0.202 ± 0.032§§§0.388 ± 0.030***0.291 ± 0.031¶¶¶
  • *P < 0.05; **P < 0.001; ***P < 0.0001, comparison with Nx; §P < 0.05; §§P < 0.01; §§§P < 0.001, comparison with Hx; P < 0.05; ¶¶P < 0.001; ¶¶¶P < 0.0001, comparison with SuHx.