Drug vs. System | Parameters | Estimates (RSE%) | IIV (RSE%) | t1/2,kout |
---|---|---|---|---|
min | ||||
System parameters | BSLHR (beats min−1) | 317. (1.4) | 24. (12) | |
BSLMAP (mm Hg) | 102. (1.7) | 7.2 (13) | ||
BSLQT (ms) | 64.3 (2.1) | 3.9 (11) | ||
FB0 | 0.00532 (0.7) | |||
PHR | 3.25 (1.1) | |||
PTPR | 1.21 (2.0) | |||
kout,QT (h−1) | 9.45 (15) | 4.4 | ||
kout,HR (h−1) | 30.7 (7.8) | 1.4 | ||
kout,TPR (h−1) | 3.8 (13) | 11 | ||
kout,SV (h−1) | 0.115 (1.7) | 360 | ||
Ivabradine | Imax,HR | 0.944 (1.7) | ||
IC50,HR (nM) | 475. (11) | |||
γHR | 0.511 (3.6) | |||
Sildenafil | Imax,TPR | 1.00 (1.3) | ||
IC50,TPR (nM) | 4.01 (5.4) | |||
γTPR | 0.63 (2.5) | |||
Dofetilide | Emax,QT | 0.195 (9.9) | ||
EC50,QT (nM) | 50.6 (93) | |||
γQT | 0.156 (21) | |||
Pimobendan | SLSV (nM−1) | 5.01*10−5 (25) | ||
Imax,TPR | 0.745 (4.6) | |||
IC50,TPR (nM) | 47.8 (16) | |||
γTPR | 0.546 (4.7) | |||
kmet (h−1) | 0.116 (14) |
IIV, interindividual variability, S.D. of the parameter within the population; t1/2,kout, equivalent half-lives for kout,.