TABLE 3

Final pharmacokinetic parameter estimates and their RSE%

CompoundCL (l h−1 kg−1)Vp (l kg−1)CLd (l h−1 kg−1)Vt (l kg−1)Ka (h−1)F (%)
Ivabradine2.88 (24)1.45 (25)0.408 (>100)0.427 (>100)0.61 (31)19 (26)
Sildenafil3.55 (33)1.29 (19)0.137 (>100)0.135 (>100)0.80 (31)1.4 (33)
Dofetilide3.50 (24)1.52 (18)0.328 (>100)0.397 (>100)0.60 (26)37 (22)
Pimobendan4.08 (18)2.71 (22)2.03 (>100)0.861 (>100)1.5 (20)21 (19)