Steady-state PV loop parameters after acetate intraperitoneal injection
| Hemodynamic parameter | Baseline (n = 7) | Saline (n = 5) | Acetate (n = 7) |
|---|---|---|---|
| HR (bpm) | 447 ± 32 | 475 ± 46 | 484 ± 37 |
| Pmax (mmHg) | 85 ± 6 | 93 ± 8 | 89 ± 14 |
| Pes (mmHg) | 77 ± 4 | 82 ± 5 | 80 ± 13 |
| Ped (mmHg) | 6 ± 3 | 8 ± 3 | 8 ± 3 |
| Ves (µl) | 19 ± 4 | 17 ± 6 | 32 ± 15 |
| Ved (µl) | 39 ± 3 | 43 ± 8 | 60 ± 19 |
| SW (mmHg*µl) | 1901 ± 282 | 2481 ± 260* | 2689 ± 977 |
| SV (µl) | 26 ± 3 | 32 ± 3 | 36 ± 10 |
| CO (µl/min) | 11736 ± 1293 | 15122 ± 2108 | 17444 ± 5323 |
| EF (%) | 65 ± 7 | 72 ± 10 | 59 ± 12 |
| dP/dt max (mmHg/s) | 6821 ± 1176 | 8289 ± 1426 | 8336 ± 2016 |
| dP/dt min (mmHg/s) | −6271 ± 1128 | −7776 ± 868* | −8317 ± 2572 |
| Tau (ms) | 9 ± 1 | 8 ± 1 | 8 ± 1 |
Pressure volume loop hemodynamic data were measured from left ventricular apex at baseline, 10 min after i.p. injection of saline, and 10 min after i.p. injection with 1.0 g/kg sodium acetate. Measurements were done at a steady state. n = 5 saline, n = 7 acetate. CO, cardiac output; EF, ejection fraction; Ped, end-diastolic pressure; Pes, end-systolic pressure; Pmax, maximum pressure; SV, stroke volume; SW, stroke work; tau, isovolumetric relaxation constant; Ved, end-diastolic volume; Ves, end-systolic volume. Values are means ± S.D.
↵* P < 0.05 vs. basal.