Summary of noncompartmental analysis results of metalloporphyrins
| F | t1/2a | Cmax | AUC0–96 | |||
|---|---|---|---|---|---|---|
| % | h | µM | µM × h | |||
| Plasma | AEOL11207 | Intravenous | 21.0 | 436 | ||
| By mouth | 23 | 38 | 2.53 | 99 | ||
| AEOL11114 | Intravenous | 11.2 | 540 | |||
| By mouth | 25 | 169 | 3.78 | 134 | ||
| Brain | AEOL11207 | Intravenous | 0.32 | 15.0 | ||
| By mouth | 0.21 | 9.3 | ||||
| AEOL11114 | Intravenous | 0.40 | 19.2 | |||
| By mouth | 0.14 | 8.7 |
F, bioavailability.
↵a The terminal half-lives in the plasma were estimated.