TABLE 1

Summary of the linear regression analysis of eq. 17

CSF/Cu,p values were taken from reference (Caruso et al., 2013). Only compounds from (Caruso et al., 2013) for which Embedded Image and Embedded Image were available to calculate AP-ER were selected. Primary data are available in the Supplemental Information.

Parametera (±S.E.)b (±S.E.)r2n
ER0.89 ± 0.100.14 ± 0.050.7134
AP-ER1.04 ± 0.10−0.03 ± 0.060.7634
  • a and b are regression coefficients. Papp (+I), apparent permeability in the presence of an inhibitor.