Summary of the linear regression analysis of eq. 17
CSF/Cu,p values were taken from reference (Caruso et al., 2013). Only compounds from (Caruso et al., 2013) for which and were available to calculate AP-ER were selected. Primary data are available in the Supplemental Information.
Parameter
a (±S.E.)
b (±S.E.)
r2
n
ER
0.89 ± 0.10
0.14 ± 0.05
0.71
34
AP-ER
1.04 ± 0.10
−0.03 ± 0.06
0.76
34
a and b are regression coefficients. Papp (+I), apparent permeability in the presence of an inhibitor.