Compound | Dose (mg/kg) | PK Parameter | |||
---|---|---|---|---|---|
CCI Model | STZ Model | ||||
Cmax (μg/ml) | AUC0–24 h (μg·h/ml) | Cmax (μg/ml) | AUC0–24 h (μg·h/ml) | ||
HSK16149 | 1 | 0.69 | 1.46 | 0.62 | 1.55 |
3 | 1.69 | 4.27 | 1.80 | 4.75 | |
10 | 6.13 | 15.41 | 4.51 | 18.94 | |
30 | 16.90 | 61.63 | 18.00 | 59.60 | |
Pregabalin | 1 | 1.43 | 5.55 | 1.67 | 6.45 |
3 | 4.26 | 20.21 | 4.49 | 20.54 | |
10 | 12.83 | 58.42 | 13.73 | 63.36 | |
30 | 30.50 | 138.89 | 28.55 | 158.95 |