TABLE 3

Summary of parameters for lysosome distribution model. Dashes, Not Available.

Tissue	Lysosome Volume^{^a}	Component Fraction^{^b}
		Interstitial Space	Cytosol		Neutral Lipid		Neutral Phospholipid		AP (mg/g)^{^c}
		Interstitial Space	Rat	Human	Rat	Human	Rat	Human	Rat	Human
	%
Liver	9.55	16.1	57.3	59.0	1.40	3.48	2.40	2.52	4.56	4.56
Kidney	3.28	27.3	48.3	51.0	1.20	2.07	2.42	1.62	5.03	5.03
Lung	2.77	33.6	44.6	47.5	2.20	0.30	1.28	0.80	3.91	3.91
Spleen	3.18	20.7	57.9	58.1	0.77	0.20	1.13	1.98	3.18	3.18
Heart	0.595	32.0	45.6	45.0	1.40	1.15	1.11	1.66	2.25	2.25
Brain	0.481	16.2	62.0	60.8	3.90	5.10	0.15	5.65	0.40	9.60
Muscle	0.126	11.8	63.0	64.2	1.00	2.38	0.72	0.72	1.53	1.53
Skin	0.096	38.2	29.1	33.6	6.00	2.84	0.44	1.11	3.18	3.18
RBC	—	—	60.3		0.17		0.29		0.50
pKa1	10.1
pKa2	8.40
Log P	4.63
pH^{^d}	Lysosome	5.0 (at 10 h)
	Cytosol	7.0
	IS and plasma	7.4
Fn	Lysosome	3.16E-09 (at 10 h)
	Cytosol	3.04E-05
	IS and plasma	1.81E-04

↵^a Calculated based on 10-h fitted data.
↵^b From Rodgers et al. (2005) and Poulin and Theil (2002).
↵^c AP concentration.
↵^d From Assmus et al. (2017).