TABLE 2

Pharmacodynamic properties of Δ9-THC, CBD, and CBG at noncannabinoid receptors

Binding affinities for Δ9-THC, CBD, and CBG at TRP ion channels, α-2 adrenoceptors, the serotonin receptor 5-HT1A, and PPARγ are presented. Values are all EC50 for agonists and IC50 for antagonists.

Δ9-THCCBDCBG
ReceptorAffinityFunctionAffinityFunctionAffinityFunction
nMnMnM
TRPA1230a,bAgonist110a,bAgonist700a,b,cAgonist
TRPV1N.D.a,bUnknown1000a,bAgonist1300a,b,cAgonist
TRPV2650a,bAgonist1250a,bAgonist1720a,b,cAgonist
TRPV39500b,dAgonist3700b,dAgonist1000b,dAgonist
TRPV4850b,dAgonist800b,dAgonist5100b,dAgonist
TRPM8160a,bAntagonist140a,bAntagonist160a,b,cAntagonist
ɑ-2 adrenoceptorN.T.UnknownN.T.Unknown0.2–72.8eAgonist
5-HT1AN.T.UnknownN.D.f,gIndirect agonist51.9d,eAntagonist
PPARγ2120hAgonist2010hAgonist1270hAgonist
  • N.D., not detected; N.T., not tested.

  • a De Petrocellis et al., 2011.

  • b Muller et al., 2019.

  • c Pollastro et al., 2011.

  • d Rock et al., 2011.

  • e Cascio et al., 2010.

  • f Russo et al., 2005.

  • g Rock et al., 2012.

  • h Granja et al., 2012.