TABLE 2

Pharmacodynamic properties of Δ9-THC, CBD, and CBG at noncannabinoid receptors

Binding affinities for Δ9-THC, CBD, and CBG at TRP ion channels, α-2 adrenoceptors, the serotonin receptor 5-HT_1A, and PPARγ are presented. Values are all EC₅₀ for agonists and IC₅₀ for antagonists.

	Δ9-THC		CBD		CBG
Receptor	Affinity	Function	Affinity	Function	Affinity	Function
	nM		nM		nM
TRPA1	230a,b	Agonist	110a,b	Agonist	700a,b,c	Agonist
TRPV1	N.D.a,b	Unknown	1000a,b	Agonist	1300a,b,c	Agonist
TRPV2	650a,b	Agonist	1250a,b	Agonist	1720a,b,c	Agonist
TRPV3	9500b,d	Agonist	3700b,d	Agonist	1000b,d	Agonist
TRPV4	850b,d	Agonist	800b,d	Agonist	5100b,d	Agonist
TRPM8	160a,b	Antagonist	140a,b	Antagonist	160a,b,c	Antagonist
ɑ-2 adrenoceptor	N.T.	Unknown	N.T.	Unknown	0.2–72.8e	Agonist
5-HT_1A	N.T.	Unknown	N.D.f,g	Indirect agonist	51.9d,e	Antagonist
PPARγ	2120h	Agonist	2010h	Agonist	1270h	Agonist

N.D., not detected; N.T., not tested.
^a De Petrocellis et al., 2011.
^b Muller et al., 2019.
^c Pollastro et al., 2011.
^d Rock et al., 2011.
^e Cascio et al., 2010.
^f Russo et al., 2005.
^g Rock et al., 2012.
^h Granja et al., 2012.