Pharmacodynamic properties of Δ9-THC, CBD, and CBG at noncannabinoid receptors
Binding affinities for Δ9-THC, CBD, and CBG at TRP ion channels, α-2 adrenoceptors, the serotonin receptor 5-HT1A, and PPARγ are presented. Values are all EC50 for agonists and IC50 for antagonists.
Δ9-THC | CBD | CBG | ||||
---|---|---|---|---|---|---|
Receptor | Affinity | Function | Affinity | Function | Affinity | Function |
nM | nM | nM | ||||
TRPA1 | 230a,b | Agonist | 110a,b | Agonist | 700a,b,c | Agonist |
TRPV1 | N.D.a,b | Unknown | 1000a,b | Agonist | 1300a,b,c | Agonist |
TRPV2 | 650a,b | Agonist | 1250a,b | Agonist | 1720a,b,c | Agonist |
TRPV3 | 9500b,d | Agonist | 3700b,d | Agonist | 1000b,d | Agonist |
TRPV4 | 850b,d | Agonist | 800b,d | Agonist | 5100b,d | Agonist |
TRPM8 | 160a,b | Antagonist | 140a,b | Antagonist | 160a,b,c | Antagonist |
ɑ-2 adrenoceptor | N.T. | Unknown | N.T. | Unknown | 0.2–72.8e | Agonist |
5-HT1A | N.T. | Unknown | N.D.f,g | Indirect agonist | 51.9d,e | Antagonist |
PPARγ | 2120h | Agonist | 2010h | Agonist | 1270h | Agonist |
N.D., not detected; N.T., not tested.
a De Petrocellis et al., 2011.
b Muller et al., 2019.
c Pollastro et al., 2011.
d Rock et al., 2011.
e Cascio et al., 2010.
f Russo et al., 2005.
g Rock et al., 2012.
h Granja et al., 2012.