Drug | Uptake Inhibition at DAT [IC50 (nM)] | Uptake Inhibition at NET [IC50 (nM)] | DAT/NET Ratio |
---|---|---|---|
Amphetamine | 122 ± 12 | 69 ± 9 | 0.56 |
AEPEA | 3366 ± 333 | 573 ± 78 | 0.16 |
MEPEA | 2248 ± 245 | 503 ± 95 | 0.22 |
DEPEA | 510 ± 38 | 427 ± 60 | 0.84 |
Release at DAT EC50 (nM) (%Emax) | Release at NET EC50 (nM) (%Emax) | ||
Amphetamine | 5 ± 1 (102) | 8 ± 1 (96) | 1.6 |
AEPEA | 273 ± 36 (101) | 80 ± 17 (100) | 0.29 |
MEPEA | 179 ± 25 (101) | 58 ± 12 (96) | 0.32 |
DEPEA | 604 ± 159 (43) | 209 ± 35 (82) | 0.35 |