TABLE 2

High-resolution liquid chromatography-tandem mass spectrometry analysis of proteins that increase or decrease ≥1.5-fold after treatment with SF-3-030 or SCH772984 for 12 h relative to untreated A375 cells (set at 1)

Protein changes common to both SF-3-030 and SCH772984 are italicized.

A.
Proteins that increase with SF-3-030Fold increase
 OSGIN121.04
 ZNF77418.18
TCF410.95
 PXDN9.43
 Protein MEMO18.37
 TTC39C7.31
 MYO18A4.50
SCO23.89
 Jouberin (AHI1)3.12
 HMOX13.02
 Protein moonraker (KIAA0753)2.26
 ASB62.07
 REPS11.98
 NOC2L1.73
 Sickle tail protein homolog (KIAA1217)1.71
 NCAPD31.49
Proteins that decrease with SF-3-030Fold decrease
 Myomegalin (PDE4DIP)2.80
 HCCS2.49
 AP1M12.24
 CNGB12.11
 FOXR21.76
 GRIP21.72
 SUN11.68
RSL24D11.66
KIAA12111.62
 INTS21.51
B.
Proteins that increase with SCH772984Fold increase
 FOXD332.88
 PKP24.76
 PABPC32.85
 WDR592.76
SCO22.69
TCF42.64
KIAA12111.84
 HBS1L1.71
 PDIA31.61
 GFPT21.48
Proteins that decrease with SCH772984Fold decrease
 CACNB42.65
 PDE5A2.18
 RFC42.08
 RNMT1.88
 ATP11A1.82
 TFAP2A1.74
RSL24D11.70
 DCN1.68
 HK21.60
 ABHD51.59
 COL1A11.48
  • ABHD5, Abhydrolase domain-containing protein 5; AHI1, Abelson helper integration site 1 protein homolog; AP1M1, AP-1 complex subunit μ-1; ASB6, ankyrin repeat and SOCS box protein 6; ATP11A, ATPase class VI type 11A; CACNB4, Calcium channel voltage-dependent subunit β 4; CNGB1, cyclic nucleotide-gated cation channel β-1; COL1A1, collagen α-1(I) chain; DCN, decorin; FOXR2, forkhead box protein R2; GFPT2, glutamine-fructose-6-phosphate aminotransferase 2; GRIP2, glutamate receptor-interacting protein 2; HBS1L, HBS1-like protein; HK2, hexokinase-2; INTS2, integrator complex subunit 2; KIAA1211, uncharacterized protein KIAA1211; MYO18A, unconventional myosin-XVIIIa; NCAPD3, condensin-2 complex subunit D3; NOC2L, nucleolar complex protein 2 homolog; PABPC3, polyadenylate-binding protein 3; PDE5A, phosphodiesterase 5A cGMP-specific; PDIA3, protein disulfide-isomerase A3; PKP2, plakophilin-2; PXDN, peroxidasin homolog; REPS1, RalBP1-associated Eps domain-containing protein 1; RFC4, replication factor C subunit 4; RNMT, mRNA cap guanine-N7 methyltransferase; SUN1, Sad1/unc-84 protein-like 1; TFAP2A, transcription factor AP-2-α; TTC39C, chromosome 18 open reading frame 17_isoform CRA_c; WDR59, WD repeat-containing protein 59. KIAA0753, moonraker; KIAA1217, Sickle tail protein homolog; PDE4DIP, Phosphodiesterase 4D-interacting protein.