TABLE 2

Topical superfusion of cromakalim or minoxidil sulfate decreased volumetric lymph flow in rat mesenteric LVs in vivo

Increasing log conc. of cromakalim or minoxidil sulfate (0.01–10 μmol/l) progressively decreased positive volumetric lymph flow compared with the DMSO solvent control (*P < 0.05, mean ± S.D., n = 5).

KCOConc. (µmol/l)Positive Volumetric Flow (% Baseline)
Cromakalim0.01121.2 ± 42.4
0.150.6 ± 22.0*
148.6 ± 23.3*
Minoxidil sulfate0.0199.7 ± 29.8
0.185.6 ± 13.6
146.4 ± 6.3*
DMSO2.82121.2 ± 49.2
28.16121.9 ± 55.9
281.58136.0 ± 65.8