TABLE 1

Solubility of veverimer in various aqueous and organic solvents

Test MediumSolubility (mg/l)a
Water0
0.1 N HCl3
Methanol0
n-Heptane0
50 mM acetate buffer (pH 4.5)0
50 mM acetate buffer (pH 4.5) with 2 wt% SDS0
50 mM acetate buffer (pH 4.5) with 2 wt% CTAB2
50 mM acetate buffer (pH 4.5) with 2 wt% Tween 800
50 mM phosphate buffer (pH 6.8)0
50 mM phosphate buffer (pH 6.8) with 2 wt% SDS0
50 mM phosphate buffer (pH 6.8) with 2 wt% CTAB0
50 mM phosphate buffer (pH 6.8) with 2 wt% Tween 800
  • Tween 80, polyoxyethylene sorbitan mono-oleate.

  • a Negative and zero results are reported as zero.