Parameter estimates (relative S.E., %) of the cycle-varying hazard base model and covariate models implementing different imputed paclitaxel pharmacokinetics exposure metrics
| Parameter | Base Model: No Covariate | Covariate Model with TC>0.01µM | Covariate Model with TC>0.05µM | Covariate Model with TC>0.1µM | Covariate Model with AUCcycle |
|---|---|---|---|---|---|
| OFV | 1344.323 | 1337.249 | 1334.563 | 1332.735 | 1328.224 |
| F, day−1 | 0.00568 (35) | 0.00500 (40) | 0.00480 (41) | 0.00460 (41) | 0.00460 (42) |
| K, day−1 | 0.0568 (42) | 0.0504 (49) | 0.0480 (52) | 0.0477 (51) | 0.0448 (55) |
| ECOV, covariate unit−1 | n.a | 0.0329 (43) | 0.0456 (38) | 0.0652 (33) | 0.0989 (29) |
ECOV, covariate effect parameter describing change in F with a unit change in paclitaxel exposure relative to the median exposure; K, first-order hazard decay rate constant.
n.a: not applicable