Body weight and plasma biochemical parameters after overnight fast in hamsters fed a control chow diet, a high-cholesterol diet, or a high-cholesterol diet supplemented with 0.01% ezetimibe over 4 wk
Mean ± S.E.M., n = 8 per group.
| Chow | High-Fat Diet (HF) | High-Fat Diet + 0.01% Ezetimibe (HFe) | |
|---|---|---|---|
| Body weight (g) | 105.9 ± 2.48 | 104.7 ± 3.21 | 103.9 ± 1.81 |
| Fasted blood glucose (mg/dl) | 106.5 ± 4.64 | 137.88 ± 8.84** | 139.75 ± 5.98*** |
| Total cholesterol (g/l) | 1.35 ± 0.05 | 2.65 ± 0.19*** | 2.04 ± 0.11*** † |
| HDL cholesterol (g/l) | 1.22 ± 0.1 | 1.57 ± 0.1* | 1.48 ± 0.03** |
| HDL cholesterol/total cholesterol | 0.96 ± 0.05 | 0.61 ± 0.07*** | 0.75 ± 0.05** |
| Free cholesterol (mg/dl) | 25.3 ± 0.94 | 48.17 ± 3.13** | 41.87 ± 1.79*** |
| Triglycerides (g/l) | 1.22 ± 0.12 | 2.7 ± 0.40** | 3.15 ± 0.29 |
| Free fatty acids (mmol/l) | 0.51 ± 0.06 | 0.47 ± 0.05 | 0.58 ± 0.03 |
| CETP activity (pmol/h per µl) | 26.08 ± 1.16 | 29.19 ± 2.14 | 26.78 ± 1.29 |
| LCAT activity (nmol/h per ml) | 350.65 ± 28.102 | 617.29 ± 47.54*** | 674.39 ± 51.57*** |
↵* P < 0.05; **P < 0.01; ***P < 0.001 vs. Chow, +P < 0.05 vs. HF.