Enhanced effect of combination of three PIs on the inhibitory potency of ME in MVD in the presence or absence of sialorphin
| PIs (10−6 M each) | IC50 (×10−9 M) | Ratio of Potency | ||
|---|---|---|---|---|
| Sia (None) | Sia (1 × 10−4 M) | Sia (None) | Sia (1 × 10−4 M) | |
| AC | 5.75 ± 0.75 | 4.18 ± 0.32 | 3.70 ± 0.59 | 5.10 ± 0.90 |
| CP | 1.98 ± 0.22 | 1.49 ± 0.12 | 10.57 ± 1.36 | 13.92 ± 1.78 |
| AP | 2.46 ± 0.27 | 0.79 ± 0.07 | 8.67 ± 1.48 | 26.68 ± 4.34* |
| ACP | 1.34 ± 0.21 | 0.83 ± 0.11 | 16.34 ± 3.24 | 26.58 ± 5.50 |
Sia, sialorphin.
Dunn’s post hoc test compared with without sialorphin, *P < 0.05, n = 4.