TABLE 2

Echocardiographic analysis of cardiac function in mice with low-dose isoproterenol (5 mg/kg per day) treatment of seven consecutive days

Data are means ± S.D.

GenotypeVehicle treatmentISO treatment
WT (n = 9)KO (n = 7)WT (n = 13)KO (n = 14)
mmmmmmmm
LVID;d4.18 ± 0.174.14 ± 0.264.31 ± 0.314.30 ± 0.30
LVID;s2.86 ± 0.222.77 ± 0.393.17 ± 0.40*3.05 ± 0.40
LVPW;s1.34 ± 0.171.24 ± 0.091.23 ± 0.181.41 ± 0.19#
IVS;d0.92 ± 0.130.95 ± 0.080.99 ± 0.160.98 ± 0.11
IVS;s1.43 ± 0.201.50 ± 0.131.43 ± 0.211.44 ± 0.19
  • IVS;d, end-diastolic interventricular septum; IVS;s, systolic interventricular septum; LVID;d, end-diastolic left ventricular internal dimension; LVID;s, systolic left ventricular internal dimension; LVPW;d, end-diastolic left ventricular posterior wall thickness; LVPW;s, systolic left ventricular posterior wall thickness.

  • * P < 0.05, compared with vehicle group.

  • # P < 0.05, compared with WT group (one-way ANOVA plus a post hoc analysis using a Bonferroni test).