TABLE 3

Echocardiographic analysis of cardiac function in high-dose isoproterenol (15 mg/kg per day)–treated mice

Data are mean ± S.D.

Genotype0 days after ISO7 days after ISO
WT (n = 9)KO (n = 6)WT (n = 9)KO (n = 6)
LV mass (mg)140.0 ± 21.13144.8 ± 32.11151.8 ± 31.59148.7 ± 14.44
LVID;d (mm)3.93 ± 0.314.09 ± 0.353.95 ± 0.164.19 ± 0.28#
LVID;s (mm)2.62 ± 0.262.74 ± 0.322.86 ± 0.343.07 ± 0.25*
LVPW;d (mm)0.98 ± 0.150.91 ± 0.071.01 ± 0.220.92 ± 0.06
LVPW;s (mm)1.43 ± 0.151.25 ± 0.101.41 ± 0.201.26 ± 0.09
IVS;d (mm)0.87 ± 0.080.89 ± 0.130.94 ± 0.110.87 ± 0.12
IVS;s (mm)1.36 ± 0.151.52 ± 0.261.42 ± 0.191.37 ± 0.13
  • IVS;d, end-diastolic interventricular septum; IVS;s, systolic interventricular septum; LVID;d, end-diastolic left ventricular internal dimension; LVID;s, systolic left ventricular internal dimension; LVPW;d, end-diastolic left ventricular posterior wall thickness; LVPW;s, systolic left ventricular posterior wall thickness.

  • * P < 0.05, compared with 0-day KO group.

  • # P < 0.05, compared with 7-day WT group (one-way ANOVA plus a post hoc analysis using a Bonferroni test).