TABLE 5

Summary overview of microdialysis, behavioral, and gene expression effects of IRL752 and selected procognitive comparators

Sources for comparator data cited: Atomoxetine: Bymaster et al., 2002; Swanson et al., 2006; Tzavara et al., 2006; Cain et al., 2011; IRL AB, unpublished data. Methylphenidate: Gerasimov et al., 2000; Bymaster et al., 2002; Marsteller et al., 2002; Berridge et al., 2006; Tzavara et al., 2006; Banerjee et al., 2009; Seu and Jentsch, 2009; Rowley et al., 2014; IRL AB, unpublished data. Clozapine: Hertel et al., 1997; Westerink et al., 2001; Ichikawa et al., 2002; Shirazi-Southall et al., 2002; Devoto et al., 2003; Shilliam and Dawson, 2005; Abdul-Monim et al., 2006; Grayson et al., 2007; Robbins et al., 2008; IRL AB, unpublished data. Cariprazine: Neill et al., 2016; Kehr et al., 2018; Huang et al., 2019; Waters et al., 2020; IRL AB, unpublished data. Vortioxetine: Mørk et al., 2013; Pehrson et al., 2013, 2018; du Jardin et al., 2014; Wallace et al., 2014; IRL AB, unpublished data. Atipamezole: Kauppila et al., 1991; Haapalinna et al., 1998; Tellez et al., 1999; Devoto et al., 2003; Lapiz and Morilak, 2006; Bondi et al., 2010; Mervaala et al., 1993; IRL AB, unpublished data. Idazoxan: Devauges and Sara, 1990; Coull et al., 1996: Hertel et al., 1997; Tellez et al., 1999; Swanson et al., 2006; Uys et al., 2017b; IRL AB, unpublished data. Fluparoxan: Tellez et al., 1999;Millan et al., 2000; Borthwick, 2017; IRL AB, unpublished data. Disclaimer: Permutations of experimental conditions and differences in set-ups between laboratories preclude direct head-to-head comparisons of efficacies and responses among agents. This applies broadly but may be particularly apparent with regard to cognitive behavioral testing.