Plasma levels of ASN008 from concentration-response studies

Single applicationaOnce-daily application for 5 daysa
ASN008 concentration in gel3%5%0.1%0.3%1%3%
ASN008 CAve (ng/ml)4.43.2<0.51.0b9.627
S.D. (ng/ml)5.23.8N/A0.395.59.2
Coefficient of variation (%)118118N/A375834
  • a N = 8 animals/group.

  • b Plasma level <0.5 ng/ml in four of eight animals; CAve calculated from plasma levels in four animals with CAve values above 0.5 ng/ml.