TABLE 1

Plasma levels of ASN008 from concentration-response studies

	Single application^{^a}		Once-daily application for 5 days^{^a}
ASN008 concentration in gel	3%	5%	0.1%	0.3%	1%	3%
ASN008 C_Ave (ng/ml)	4.4	3.2	<0.5	1.0^{^b}	9.6	27
S.D. (ng/ml)	5.2	3.8	N/A	0.39	5.5	9.2
Coefficient of variation (%)	118	118	N/A	37	58	34

↵^a N = 8 animals/group.
↵^b Plasma level <0.5 ng/ml in four of eight animals; C_Ave calculated from plasma levels in four animals with C_Ave values above 0.5 ng/ml.