TABLE 4

Comparison of the peak effects of IRL752 on extracellular amines in different brain regions

Shown is the peak effect of IRL752 (50 ┬Ámol/kg = 10.7 mg/kg, s.c) expressed as % of baseline in dorsal hippocampus, ventral hippocampus, nucleus accumbens, PFC, and striatum.

Dorsal HippocampusVentral HippocampusNucleus AccumbensFrontal CortexStriatum
DA150%250%N.E.285%N.E.
NA250%370%130%380%160%
5-HT170%150%150%220%170%
  • N.E., no effect (<120% of baseline).