TABLE 3

Summary of effects of IRL752 on rat motor activity under different cotreatment conditions

Data expressed as accumulated motor activity counts 0–60 min, percent of corresponding vehicle controls, mean ± S.E.M. (n).

CotreatmentVehicle ControlsCotreatment Challenge Alone+IRL752 (µmol/kg, s.c.)
3.71133100
Untreated100 ± 32 (4)N/A116 ± 20 (4)140 ± 14 (4)150 ± 35 (4)130 ± 23 (4)
Habituated100 ± 24 (5)N/A66 ± 24 (5)49 ± 11 (5)125 ± 10 (5)
d-Amphetamine 1.5 mg/kg, i.p.100 ± 7 (4)314 ± 40 (4)*337 ± 44 (4)*286 ± 44 (4)*310 ± 73 (4)*
MK-801
 0.2 mg/kg, i.p.100 ± 10 (5)358 ± 90 (5)*302 ± 68 (5)*203 ± 17 (5)*
 0.7 mg/kg, i.p.100 ± 13 (4)951 ± 210 (4)*511 ± 68 (4)*1182 ± 111 (4)*1294 ± 300 (4)*
Tetrabenazine 0.64 mg/kg, s.c.100 ± 10 (10)50 ± 5 (10)*60 ± 7 (10)91 ± 10 (10)#
  • N/A, not applicable.

  • * P < 0.025 or less vs. corresponding vehicle controls.

  • # P < 0.005 vs. corresponding cotreatment challenge group.