TABLE 2

Parameters comparison between observed and predicted values Data are presented as mean ± S.D.

CompoundDose (mg/kg)Cmax (nM)AUCinf (nM*h)t1/2 (h)koff (h−1)sEHtotal (nmol)
ObservedPredictedObservedPredictedObservedPredictedObservedPredictedObservedPredicted
TPPU0.3436 ± 319390 ± 25012,100 ± 463012,700 ± 336054.3 ± 17.558.6 ± 9.332.09 (Lee et al., 2013)2.2410.0 (Lee et al., 2019)16.2
TCPU1.0853 ± 207971 ± 19622,800 ± 372021,900 ± 334015.2 ± 2.6416.3 ± 1.681.76 (Lee et al., 2013)2.67
3.09220 ± 29408740 ± 3150159,000 ± 17,800144,000 ± 33,40010.5 ± 4.6711.6 ± 2.15
10.057,300 ± 11,60049,800 ± 95701200,000 ± 85,500102,000 ± 162,00011.6 ± 0.8611.7 ± 0.56
  • AUCinf, area under the concentration time curve from predose extrapolated to infinity; Cmax, maximum concentration; sEHtotal, sEH total amount in rat body; t1/2, terminal elimination half-life.