Gene expression of cholesterol and bile acid metabolism–related genes in jejunum.
Genes were categorized according to biologic mechanism. Data are presented as means ± S.D. (each group, n = 7 animals). Data were analyzed by one-way ANOVA, followed by Tukey’s post hoc test. Significance was set at P < 0.05. The 95% CI and the P-value are listed.
| Fold Change of C | |||||||
|---|---|---|---|---|---|---|---|
| Category | Gene Name | C | F | E | F+E | 95% CI | P-Value |
| Cholesterol homeostasis | |||||||
| NPC1L1 | 1.0 ± 0.4 | 1.1 ± 0.4 | 1.8 ± 1.1 | 1.2 ± 0.7 | −39% to 70% | 0.978, C vs. F+E | |
| Abca1 | 1.0 ± 0.9 | 0.9 ± 0.6 | 0.6 ± 0.2 | 0.8 ± 0.2 | 8%–36% | 0.891, C vs. F+E | |
| Abcg5 | 1.0 ± 0.4 | 2.1 ± 0.8 | 1.9 ± 0.5 | 3.4 ± 2.3 | 77%–411% | 0.006, C vs. F+E | |
| Abcg8 | 1.0 ± 0.4 | 6.4 ± 3.3 | 3.8 ± 3.7 | 9.4 ± 7.3 | 302%–1381% | 0.008, C vs. F+E | |
| LDLR | 1.0 ± 0.4 | 1.1 ± 0.4 | 1.4 ± 0.6 | 1.0 ± 0.3 | −16% to 27% | 0.996, C vs. F+E | |
| SR-B1 | 1.0 ± 0.4 | 0.6 ± 0.2 | 1.5 ± 0.9 | 0.7 ± 0.5 | 48%–65% | 0.044, F vs. E | |
| Bile acid transporter | |||||||
| Asbt | 1.0 ± 0.5 | 7.1 ± 3.5 | 4.1 ± 2.3 | 10.7 ± 8.5 | 345%–1602% | 0.004, C vs. F+E | |
| Ostα | 1.0 ± 0.5 | 1.2 ± 0.6 | 1.9 ± 1.0 | 1.6 ± 1.3 | −36% to 154% | 0.612, C vs. F+E | |
| Ostβ | 1.0 ± 0.3 | 1.4 ± 0.8 | 2.3 ± 1.1 | 1.7 ± 1.1 | −9% to 156% | 0.419, C vs. F+E | |
LDLR, low-density lipoprotein receptor.