TABLE 3

Single-dose toxicokinetic parameters for ALD403 in rats

DosageSextmaxCmaxAUC0–tlastAUC0–inft1/2CLVz
mg/kghµg/mlµg·h/mlµg·h/mlhml/h·kgml/kg
10M0.01730224,99828,2051200.35561.5
F0.01730121,10226,3511550.38084.8
30M0.01777467,82281,4481380.36873.4
F0.01777072,479RNRRNRRNRRNR
100M0.0172629203,424226,3131050.44267.2
F0.0172313164,289180,8711020.55381.4
  • AUC0–inf, area under the plasma concentration-time curve from time zero extrapolated to infinity; AUC0–tlast, area under the plasma concentration-time curve from time zero to the time of the last quantifiable ALD403 concentration; CL, total body clearance; Cmax, maximum observed concentration; F, female; M, male; RNR, result not reported as the AUC0–inf was extrapolated by more than 20% or the R2 was <0.800; t1/2, terminal half-life; Tmax, time at maximal concentration; VZ, apparent volume of distribution during terminal elimination phase.