TABLE 2

Binding constants of ALD403 to different CGRP molecules

CGRP moleculekakdKD
M−1s−1s−1M
Human alpha2.6E+051.0E−064E−12
Human beta2.9E+051.0E−063E−12
Rat alpha3.9E+056.4E−051.7E−10
Rat beta5.8E+055.1E−068.4E−12
  • ka, on-rates for binding affinity; kd, off-rates for binding affinity; KD, binding affinity constant (kd/ka).