Affinity of ALD403 for Fcγ receptors
| Receptor | Antibody | ka | kd | KD |
|---|---|---|---|---|
| M−1s−1 | s−1 | M | ||
| FcγRI | ALD403 | 8.19 E+04 | 5.95 E−02 | 7.26 E−07 |
| Human IgG | 1.17 E+05 | 2.03 E−03 | 1.74 E−08 | |
| FcγRIIA | ALD403 | NMB | NMB | NMB |
| Human IgG | 2.38 E+05 | 4.46 E−01 | 1.87 E−06 | |
| FcγRIIB/C | ALD403 | NMB | NMB | NMB |
| Human IgG | 1.36 E+05 | 5.30 E−01 | 3.88 E−06 | |
| FcγRIIIA | ALD403 | NMB | NMB | NMB |
| Human IgG | 5.29 E+04 | 8.79 E−02 | 1.66 E−06 | |
| FcγRIIIB | ALD403 | NMB | NMB | NMB |
| Human IgG | 7.46 E+04 | 5.10 E−01 | 6.84 E−06 |
NMB, no measurable binding.