TABLE 2

Effect of morphine, An2-M6G, and An2-morphine on the gastrointestinal tract motility

Saline, MS (1, 5 and 10 mg/kg), An2-M6G (4 and 20 mg/kg), and An2-morphine (20 mg/kg) were injected subcutaneously 30 min before force-feeding with a charcoal meal solution. The progression of the charcoal meal in the intestine was measured 1 h after force-feeding.

TreatmentSalineMorphine Sulfate (MS)An2-M6GAn2-morphine
n10101010101010
Dose (mg/kg)151042020
Equimolar MS155.5
Progression of the charcoal meal in the intestine (% ± S.E.M.)73.4 ± 2.258 ± 2.7*49.7 ± 2.7***28.6 ± 3.7****61.5 ± 3.359.7 ± 3.1$45.1 ± 5.1****
  • MS, morphine sulfate.

  • * P < 0.05, ***P < 0.001, and ****P < 0.0001 compared with saline group; $P < 0.05 An2-M6G (20 mg/kg) compared with An2-morphine (20 mg/kg); Kruskal-Wallis nonparametric test followed by Dunn’s multiple comparison test.