Schild analysis of antagonism by morphine, oxycodone, hydrocodone, and fentanyl of human μ-opioid receptor by [35S]-GTPγS–binding assay
Values of Schild slope are means and 95% confidence intervals. Mean of three independent experiments carried out in duplicate.
| Morphine | Oxycodone | Hydrocodone | Fentanyl | |
|---|---|---|---|---|
| Naldemedine | 1.37 (1.32–1.42) | 1.29 (1.25–1.34) | 1.43 (1.35–1.51) | 1.37 (1.28–1.47) |
| Naloxone | 1.00 (0.89–1.11) | 0.97 (0.92–1.02) | 1.04 (0.98–1.09) | 1.00 (0.90–1.09) |
| Naloxegol | 0.98 (0.94–1.02) | 1.00 (0.94–1.06) |